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Human renin granules: ultrastructural aspects.

G Zavagli, A Aleotti, A Farinelli

    Nephron
    |January 1, 1983
    PubMed
    Summary
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    Human renin granules in Bartter

    Area of Science:

    • Cell Biology
    • Endocrinology
    • Nephrology

    Background:

    • Renin is a key enzyme in the renin-angiotensin-aldosterone system, regulating blood pressure.
    • Bartter's syndrome is a rare genetic disorder affecting kidney salt reabsorption, often associated with renin-angiotensin-aldosterone system abnormalities.

    Purpose of the Study:

    • To investigate the ultrastructure of human renin granules in a patient with Bartter's syndrome.
    • To correlate renin granule morphology with renin synthesis and release rates.

    Main Methods:

    • Electron microscopy was used to examine the ultrastructure of renin granules.
    • Morphological analysis focused on granule shape and its potential implications for renin activity.

    Main Results:

    Related Experiment Videos

    • Renin granules exhibited diverse morphologies: roundish (R), lobulated (L), and sharply angulated (SA).
    • Sharply angulated granules correlated with the highest renin synthesis rates and pressor enzyme concentrations.
    • Granule shapes were consistent with monoclinic crystal growth patterns in an isotropic medium.

    Conclusions:

    • Renin granule shape is a significant indicator of renin synthesis and release activity.
    • The ultrastructural findings provide insights into the biogenesis and release mechanisms of renin in pathological conditions like Bartter's syndrome.