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Related Experiment Videos

Traveler's diarrhea: update 1983.

B D Weiss

    American Family Physician
    |April 1, 1983
    PubMed
    Summary

    Traveler's diarrhea affects over a million Americans annually, often caused by E. coli. Trimethoprim-sulfamethoxazole shows promise for safe and effective prevention and treatment in children, potentially avoiding widespread prophylaxis.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Pediatric Medicine

    Background:

    • Traveler's diarrhea impacts over one million Americans yearly, primarily caused by toxin-producing Escherichia coli.
    • Current preventive measures like bismuth subsalicylate and doxycycline are unsuitable for pediatric travelers.
    • Trimethoprim-sulfamethoxazole is an established effective option for adult travelers.

    Purpose of the Study:

    • To evaluate the safety and efficacy of trimethoprim-sulfamethoxazole for pediatric traveler's diarrhea.
    • To explore the potential for targeted medication use rather than widespread prophylaxis.

    Main Methods:

    • Review of existing literature on traveler's diarrhea treatment and prevention.
    • Analysis of safety data for trimethoprim-sulfamethoxazole in pediatric populations.
    • Assessment of E. coli's role in traveler's diarrhea.

    Main Results:

    • Trimethoprim-sulfamethoxazole is deemed safe for pediatric use.
    • The drug's efficacy for prophylaxis and treatment in children warrants further investigation.
    • Current adult regimens are not ideal for children.

    Conclusions:

    • Trimethoprim-sulfamethoxazole presents a potentially safe and effective option for pediatric traveler's diarrhea.
    • Further research is needed to confirm efficacy and establish optimal dosing for children.
    • Personalized medication strategies may reduce the need for broad prophylactic measures.

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