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Related Experiment Videos

Effect of verapamil on left ventricular function: a randomized, placebo-controlled study.

R E Vlietstra, M A Farias, R L Frye

    The American Journal of Cardiology
    |April 1, 1983
    PubMed
    Summary
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    Verapamil reduced blood pressure and systemic vascular resistance in patients with suspected coronary artery disease. However, it did not improve left ventricular ejection fraction or regional wall motion, indicating a negative inotropic effect.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Verapamil is known to have a negative inotropic action in isolated cardiac muscle.
    • The effects of verapamil on overall left ventricular function in patients with suspected coronary artery disease require further investigation.

    Purpose of the Study:

    • To evaluate the effects of verapamil on left ventricular function in patients with suspected coronary artery disease.
    • To assess the impact of verapamil on hemodynamic parameters, including blood pressure, cardiac index, and systemic vascular resistance.

    Main Methods:

    • A double-blind, randomized, placebo-controlled study was conducted.
    • Twenty-five patients with suspected coronary artery disease received verapamil (0.2 mg/kg over 10 minutes) or placebo.

    Related Experiment Videos

  • Left ventricular function and hemodynamic parameters were assessed.

    • Main Results:

    • Verapamil significantly lowered mean arterial pressure and reduced systemic vascular resistance.
    • A significant increase in cardiac index and left ventricular end-diastolic volume index was observed.
    • No significant changes were noted in heart rate, left ventricular end-diastolic pressure, ejection fraction, or regional wall motion.

    Conclusions:

    • Verapamil demonstrates a negative inotropic effect, evidenced by increased left ventricular end-diastolic volume index.
    • While verapamil reduces afterload, it does not improve left ventricular ejection fraction or regional myocardial function in this patient group.
    • The findings suggest that verapamil's utility in improving cardiac performance in patients with suspected coronary artery disease may be limited.