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Related Experiment Videos

Membranous glomerulopathy associated with captopril therapy.

S C Textor, G N Gephardt, E L Bravo

    The American Journal of Medicine
    |April 1, 1983
    PubMed
    Summary

    Captopril treatment can cause membranous glomerulonephritis, leading to persistent kidney damage. Even after stopping the drug, kidney deposits and proteinuria may not fully resolve, impacting renal function.

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    Area of Science:

    • Nephrology
    • Pharmacology

    Background:

    • Hypertension is a common condition often managed with medications like captopril.
    • Membranous glomerulopathy is a kidney disease characterized by thickening of the glomerular basement membrane.

    Observation:

    • Two patients developed nephrotic syndrome and membranous glomerulonephritis during captopril therapy.
    • Both patients had pre-existing renal impairment and received high-dose captopril (600 mg/day).

    Findings:

    • Captopril discontinuation resulted in temporary proteinuria reduction but not full recovery.
    • Persistent subepithelial deposits were observed on repeat biopsies months after stopping captopril.
    • Glomerular filtration rate declined, suggesting drug-induced arterionephrosclerosis.

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    Implications:

    • Captopril-associated membranous glomerulonephritis may not be readily reversible.
    • Persistent proteinuria and renal function decline can occur despite drug cessation.
    • This challenges previous reports suggesting easy reversibility of captopril-induced kidney injury.