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Mitomycin-associated renal failure. Case report and review.

R W Hamner, R Verani, E J Weinman

    Archives of Internal Medicine
    |April 1, 1983
    PubMed
    Summary

    Mitomycin chemotherapy can cause kidney failure and anemia, even without hemolysis. This case highlights the importance of considering mitomycin-induced nephrotoxicity in patients developing renal issues during treatment.

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    Area of Science:

    • Nephrology
    • Oncology
    • Pathology

    Background:

    • Mitomycin chemotherapy is a known cause of renal failure.
    • This renal failure is often linked to microangiopathic hemolytic anemia.
    • However, renal failure can occur without overt hemolysis.

    Observation:

    • A 45-year-old male patient developed renal failure and anemia.
    • These symptoms appeared five months after initiating chemotherapy with mitomycin, fluorouracil, and doxorubicin hydrochloride.
    • The patient showed no evidence of hemolysis.

    Findings:

    • Kidney biopsy revealed fibrin thrombi in glomeruli and small arteries.
    • These findings are indicative of thrombotic microangiopathy.
    • The patient's condition necessitated maintenance dialysis.

    Implications:

    • This case underscores mitomycin-induced nephrotoxicity as a critical diagnostic consideration.
    • Early recognition and management are crucial for patients undergoing mitomycin chemotherapy.
    • Further research into the mechanisms and prevention of this adverse effect is warranted.

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