[Effect of different infusion regimens on the hormonal and metabolic reaction before, during and after...

18 metabolically healthy female patients with cholelithiasis, who had to undergo cholecystectomy, were divided into 3 groups and studied for a 4-day period. Group I, n = 6, received beginning on the operationday 0,19 g/kg BW X h of a polyol-mixture-solution (Sorbitol/Xylitol 1:1) and 0,86 g 1-crystalline amino acids (AA)/kg BW X day. Group II, n = 6, received beginning 24 h preoperatively only 1,14 g 1-crystalline AA/kg BW X day. Group III, n = 6, received beginning 24 h preoperatively 0,07 g Xylitol/kg BW X h, 0,03 g Glucose/kg BW X h and 1,14 g 1-crystalline AA/kg BW X day. In this study we could demonstrate that the pre-, intra- and postoperative hormonal and metabolic response is strongly influenced by different infusion regimens. Only by the simultaneous infusion of carbohydrate together with AA during the preoperative period a significant drop of triiodothyronine can be avoided. The rise of insulin and cortisol in the early postoperative period is augmented by the infusion of carbohydrates together with AA. There was no difference in growth hormone response to surgery between group I-III. All 3 groups showed a continuous fall of cholesterol during the study period.