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Cimetidine and renal allograft rejection
Israel Journal of Medical Sciences
|February 1, 1983
Summary
Cimetidine may harm kidney transplant recipients by affecting graft acceptance. Discontinuing this H2 receptor antagonist reversed graft deterioration, suggesting an immunological effect.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Background:
- Cimetidine, an H2 receptor antagonist, is used to prevent gastroduodenal issues in renal transplant patients.
- Concerns exist regarding cimetidine's potential immunoregulatory effects and interference with graft acceptance.
Observation:
- Two kidney allograft recipients experienced acute graft deterioration during cimetidine therapy.
- Graft function significantly improved upon cessation of cimetidine treatment.
Findings:
- Cimetidine administration was linked to acute graft deterioration in renal transplant recipients.
- Reversal of graft deterioration after discontinuing cimetidine suggests an immunological mechanism.
Implications:
- Cimetidine may have adverse immunological effects in renal transplant recipients.
- Caution is advised when using cimetidine in this patient population due to potential graft interference.