Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of catecholamines on gastrin release.

J R Hayes, J Ardill, R G Shanks

    Metabolism: Clinical and Experimental
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The IMAP-Ultra Energetic Neutral Atom (ENA) Imager.

    Space science reviews·2025
    Same author

    Observations on the Febrile Movement in Disease: An Essay Read before the Rock Island Co. Medical Society, and Published at Their Requst, April 14th, 1858.

    The Chicago medical journal·2023
    Same author

    Nasal Polypi Cured with One Dose of Aurum-M,<sup>50m</sup>.

    The Homoeopathic physician·2023
    Same author

    High spatial-density, cladding-pumped 6-mode 7-core fiber amplifier for C-band operation.

    Optics express·2021
    Same author

    Low-loss Kagome hollow-core fibers operating from the near- to the mid-IR.

    Optics letters·2017
    Same author

    Optoelectronic oscillator incorporating hollow-core photonic bandgap fiber.

    Optics letters·2017

    Catecholamines, like epinephrine, increase gastrin release by stimulating beta-adrenergic receptors. This suggests catecholamines directly impact G cell function, influencing hormone secretion.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Pharmacology

    Background:

    • Gastrin, a key hormone regulating gastric acid secretion, is influenced by various physiological factors.
    • The role of catecholamines, such as epinephrine, in modulating gastrin release requires further elucidation.

    Purpose of the Study:

    • To investigate the direct effects of catecholamines on gastrin release using both in vivo and in vitro models.
    • To determine the specific adrenergic receptor subtypes involved in catecholamine-mediated gastrin secretion.

    Main Methods:

    • In vivo studies involved intravenous infusion of epinephrine, isoproterenol, and phenylephrine in dogs, with plasma gastrin levels measured.
    • Beta-adrenergic receptor blockade was assessed using propranolol.
    • In vitro studies utilized isolated rat antrum tissue to examine the direct effects of isoproterenol and phenylephrine on gastrin release.

    Related Experiment Videos

    Main Results:

    • Intravenous epinephrine infusion in dogs significantly increased plasma gastrin concentrations.
    • Propranolol administration blocked the epinephrine-induced rise in gastrin, indicating a role for beta-adrenergic receptors.
    • Isoproterenol (a beta-agonist) stimulated gastrin release, while phenylephrine (an alpha-agonist) had no significant effect.
    • In vitro, isoproterenol stimulated gastrin release from rat antrum, whereas phenylephrine did not.

    Conclusions:

    • Catecholamines directly influence G cell function, leading to altered gastrin release.
    • The beta-adrenergic pathway is critically involved in mediating the effects of catecholamines on gastrin secretion.