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Related Experiment Videos

Immunologic-mediated eustachian tube obstruction: a double-blind crossover study.

R A Friedman, W J Doyle, M L Casselbrant

    The Journal of Allergy and Clinical Immunology
    |May 1, 1983
    PubMed
    Summary

    Seasonal allergic rhinitis triggers eustachian tube obstruction in patients. This allergy-induced dysfunction impacts nasal function and can persist for days, suggesting a link to middle ear issues.

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    Area of Science:

    • Otolaryngology
    • Allergy and Immunology
    • Respiratory Medicine

    Background:

    • Seasonal allergic rhinitis is a common condition affecting nasal passages.
    • Eustachian tube (ET) dysfunction can lead to middle ear problems like otitis media with effusion.
    • The direct link between allergic rhinitis and ET dysfunction is not fully understood.

    Purpose of the Study:

    • To investigate the effect of specific pollen antigen challenge on eustachian tube function in subjects with seasonal allergic rhinitis.
    • To assess changes in nasal function and clinical symptoms following antigen challenge.

    Main Methods:

    • Eight subjects with confirmed seasonal allergic rhinitis underwent a double-blind, placebo-controlled intranasal pollen challenge (ragweed or timothy grass).
    • Nasal function was measured using nasal rhinomanometry.

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  • Eustachian tube function was assessed using the nine-step tympanometry test before and after antigen challenge for up to 14 days.
  • Pine pollen was used as a control antigen.

    • Main Results:

    • All subjects developed allergic rhinitis symptoms, including rhinorrhea and nasal obstruction, after challenge with sensitive pollen.
    • Within 30 minutes, all 14 evaluated ears showed transient eustachian tube obstruction and inability to dilate.
    • ET function normalized within 2 hours in 3 ears, but persisted for over 3 days in 6 ears.
    • Control challenge with pine pollen did not affect ET function, nasal function, or symptoms.

    Conclusions:

    • Allergen challenge in patients with seasonal allergic rhinitis causes acute eustachian tube obstruction.
    • These findings suggest an allergic etiology for eustachian tube dysfunction.
    • The study proposes a potential link between allergic rhinitis-induced ET obstruction and the development of otitis media with effusion.