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Respiratory muscle failure.

D F Rochester, N S Arora

    The Medical Clinics of North America
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Respiratory muscle fatigue, especially low-frequency fatigue, causes hypercapnic respiratory failure. Treatment involves resting muscles, mechanical ventilation, and addressing underlying issues.

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    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Hypercapnic respiratory failure often involves compromised respiratory muscles.
    • Factors like increased work of breathing and metabolic derangements contribute to muscle fatigue.

    Purpose of the Study:

    • To review the mechanisms and clinical implications of respiratory muscle fatigue.
    • To discuss current and potential treatments for inspiratory muscle fatigue.

    Main Methods:

    • Literature review of respiratory muscle physiology and clinical studies.
    • Analysis of factors contributing to respiratory muscle fatigue and failure.

    Main Results:

    • Respiratory muscle fatigue has high and low-frequency components, with low-frequency fatigue being clinically significant.

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  • Symptoms of inspiratory muscle fatigue include dyspnea and abnormal breathing patterns.

    • Conclusions:

    • Inspiratory muscle fatigue necessitates ventilatory support and correction of underlying conditions.
    • Pharmacological agents and inspiratory muscle training show potential but require further research.