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Related Experiment Videos

Circannual changes in immune function.

J P MacMurray, J P Barker, J D Armstrong

    Life Sciences
    |May 16, 1983
    PubMed
    Summary
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    Seasonal changes in adrenocortical activity impact immune function. Winter

    Area of Science:

    • Immunology
    • Endocrinology
    • Cancer Research

    Background:

    • Adrenocortical activity exhibits circannual variation, with higher secretion in winter.
    • This seasonal fluctuation influences immune function, particularly T-cell and B-cell activity.
    • Adrenal corticosteroids, like glucocorticoids, suppress cellular immunity.

    Purpose of the Study:

    • To investigate the circannual patterns of immune function related to adrenocortical activity.
    • To explore the link between seasonal immune changes and lymphoproliferative cancer risk.
    • To examine the relationship between ambient temperature and serum immunoglobulin levels.

    Main Methods:

    • Analysis of seasonal variations in adrenocortical activity and immune cell function.
    • Measurement of serum immunoglobulin levels across different seasons.

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  • Correlation of immune parameters with ambient temperature data.

    • Main Results:

    • Observed winter-associated depression of T-cell function and elevation of B-cell function.
    • Detected increased serum immunoglobulin levels during winter.
    • Found an inverse relationship between ambient temperature and serum immunoglobulin levels.

    Conclusions:

    • Circannual immune function patterns, driven by adrenocortical activity, may influence lymphoproliferative cancer risk.
    • Seasonal immune modulation could be relevant in contexts like organ transplantation and latitude-dependent disease incidence.