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[Death from or in asthma ? (author's transl)].

H Illig

    Medizinische Klinik
    |March 10, 1978
    PubMed
    Summary

    Severe asthma deaths often stem from non-airway causes like pneumothorax or pulmonary embolism. Middle-aged patients with recent-onset asthma are at higher risk, influenced by awareness and treatment adherence.

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    [Synthetic depot-ACTH, plasmacortisol levels, and asthmatic syndrome (author's transl)].

    Medizinische Klinik·1975

    Area of Science:

    • Pulmonology
    • Critical Care Medicine
    • Pathology

    Context:

    • Analysis of 23 fatal cases of severe asthmatic dyspnea.
    • Investigated the discrepancy between clinical presentation and autopsy-confirmed causes of death.
    • Focused on identifying underlying factors contributing to mortality in asthma patients.

    Purpose:

    • To determine the correlation between clinical symptoms and the actual cause of death in severe asthma.
    • To highlight less common but critical causes of mortality in asthma patients.
    • To identify patient profiles and contributing factors associated with acute asthma fatalities.

    Summary:

    • Post-mortem examinations revealed that in 14 out of 23 severe asthma deaths, the primary cause was unrelated to airway obstruction.
    • Significant findings included spontaneous pneumothorax (5 cases) and pulmonary embolism (3 cases) as primary causes of death.
    • Other identified causes included tumor invasion, arterial thrombosis, hemorrhagic pancreatitis, and myocardial infarction.
    • Acute asthma fatalities were more common in middle-aged individuals with asthma duration less than two years.
    • Factors contributing to mortality included lack of awareness of severity, cessation of corticosteroid therapy, and bronchodilator overuse.

    Impact:

    • Underscores the importance of considering non-airway pathologies in fatal asthma cases.
    • Informs diagnostic and therapeutic strategies for managing severe asthma exacerbations.
    • Highlights the need for improved patient and physician awareness regarding asthma severity and management adherence.

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