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Ascorbic acid in bronchial asthma.

R Anderson, I Hay, H A van Wyk

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |April 23, 1983
    PubMed
    Summary
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    This study found that supplementing standard asthma treatment with ascorbic acid (vitamin C) improved immune responses in children. However, it did not significantly impact exercise-induced bronchoconstriction.

    Area of Science:

    • Pediatric Pulmonology
    • Clinical Immunology
    • Nutritional Science

    Background:

    • Bronchial asthma is a common chronic respiratory disease in children.
    • Exercise-induced bronchoconstriction (EIB) is a significant symptom in pediatric asthma.
    • Ascorbic acid (vitamin C) is investigated for its potential immunomodulatory effects.

    Purpose of the Study:

    • To evaluate the effect of ascorbic acid supplementation on bronchial asthma in children.
    • To assess ascorbic acid's impact on exercise-induced bronchoconstriction.
    • To investigate changes in immunological markers with ascorbic acid therapy.

    Main Methods:

    • A 6-month randomized controlled trial involving 16 children with bronchial asthma.
    • Two groups: standard anti-asthma chemoprophylaxis (SAC) and SAC plus 1g daily ascorbic acid.

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  • Immunological assessments included polymorphonuclear leucocyte (PMNL) function, immunoglobulins, complement levels, and viral antibody titers.

    • Main Results:

    • Ascorbic acid supplementation did not significantly affect exercise-induced bronchoconstriction.
    • Slight, non-significant immunological changes were noted in the standard care group.
    • The ascorbic acid group showed significantly improved PMNL motility, decreased antistreptolysin O (ASO) levels, and reduced IgE and viral antibody titers.

    Conclusions:

    • Ascorbic acid supplementation may offer modest benefits in modulating immune responses in children with asthma.
    • Further research is needed to confirm the clinical efficacy of ascorbic acid for asthma management, particularly regarding EIB.