Lysosomal enzymes in ocular tissues and diseases

Lysosomal enzymes are distributed widely in various ocular tissues. Among these tissues, the uvea and retina show the higher enzyme activities of acid phosphates, beta-blucuronidase, alpha-fucosidase, alpha-mannosidase, arylsulfatase, cathepsin D, cathepsin B and others. The particular role of lysosomal enzymes in the pathogenic processes of ocular diseases such as storage disease, uveitis, retinal degeneration, retinal detachment, corneal dystrophy and glaucoma is strongly suggested. The enzymes also have additional importance in ocular physiopathology.