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Hyperparathyroidism and pregnancy.

D K Lowe, E S Orwoll, M R McClung

    American Journal of Surgery
    |May 1, 1983
    PubMed
    Summary
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    Hyperparathyroidism in pregnancy requires careful management. Surgical parathyroidectomy is safe for symptomatic cases, while mild hypercalcemia can be monitored nonoperatively with good outcomes for mother and fetus.

    Area of Science:

    • Obstetrics and Gynecology
    • Endocrinology
    • Surgical Management

    Background:

    • Hyperparathyroidism can complicate pregnancies, potentially affecting maternal and fetal health.
    • Management strategies for hyperparathyroidism during gestation require careful consideration.

    Purpose of the Study:

    • To evaluate the outcomes of pregnancies in mothers with hyperparathyroidism.
    • To assess the safety and efficacy of parathyroidectomy during pregnancy.
    • To provide guidance on managing hypercalcemia in pregnant patients.

    Main Methods:

    • Presentation of six pregnancies in four mothers with hyperparathyroidism.
    • Review of 49 previously reported cases.
    • Analysis of outcomes following nonoperative management and parathyroidectomy.

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    Main Results:

    • All six presented pregnancies had satisfactory outcomes.
    • Parathyroidectomy was performed in two cases during the second trimester with successful results.
    • Nonoperative management of mild, asymptomatic hypercalcemia also yielded satisfactory maternal and fetal outcomes.

    Conclusions:

    • Parathyroidectomy is indicated for symptomatic hypercalcemia in pregnancy and is safely performed in the second trimester.
    • Pregnant women with mild, asymptomatic hypercalcemia can be managed nonoperatively with favorable outcomes.