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PACBERG: an adaptive program for controlling the blood sugar.

G Pacini, R N Bergman

    Computer Programs in Biomedicine
    |February 1, 1983
    PubMed
    Summary

    PACBERG is a new computer program that automatically controls blood sugar levels. It maintains steady or elevated glucose concentrations by estimating insulin action and calculating necessary glucose infusions.

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    Area of Science:

    • Biomedical Engineering
    • Endocrinology
    • Computational Biology

    Background:

    • Maintaining stable plasma glucose concentrations is crucial for metabolic research and clinical management.
    • Automated glucose control systems are needed to precisely manage blood sugar levels during various experimental conditions.

    Purpose of the Study:

    • To describe PACBERG, a novel computer program for automated blood glucose control (clamping).
    • To validate PACBERG's ability to maintain euglycemic and hyperglycemic levels during insulin infusions.

    Main Methods:

    • Implementation of a minimal mathematical model of glucose kinetics on a minicomputer.
    • Real-time estimation of insulin-dependent glucose disappearance rate (X) from plasma glucose concentration.
    • Calculation of exogenous glucose infusion rate (INF) required for glucose clamping.

    Main Results:

    • PACBERG successfully maintained desired basal (euglycemic) and elevated (hyperglycemic) plasma glucose levels.
    • The program accurately estimated insulin action (X) in real-time.
    • The calculated insulin sensitivity (SI) provides a quantitative measure of insulin's effect.

    Conclusions:

    • PACBERG offers a reliable method for automated glucose clamping in research settings.
    • The program's real-time insulin sensitivity calculation enhances its utility for studying glucose metabolism.
    • PACBERG's implementation in BASIC allows for broad accessibility on various computing platforms.

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