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Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro.

D Heinzmann, R Nadrowitz, W Besch

Experimental and Clinical Endocrinology

|January 1, 1983

Summary

High-dose irradiation impairs pancreatic islet insulin secretion and hormone content. These findings are crucial for understanding radioimmunosuppression applications in islet transplantation.

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Area of Science:

Endocrinology
Radiation Biology
Transplantation Science

Background:

Pancreatic islets are vital for glucose homeostasis.
Islet transplantation is a therapeutic strategy for diabetes.
Radiation is used for immunosuppression in transplantation.

Purpose of the Study:

To investigate the effects of irradiation on pancreatic islet function in vitro.
To determine the impact of varying radiation doses on insulin and glucagon secretion and content.

Main Methods:

Rat pancreatic islets were irradiated at doses of 2.5 Gy and 25 Gy.
Insulin and glucagon secretion were measured in response to glucose and IBMX stimulation.
Insulin and glucagon content in irradiated islets were quantified.

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Main Results:

Irradiation up to 2.5 Gy did not affect glucose- or IBMX-stimulated insulin secretion or hormone content.
A dose of 25 Gy resulted in decreased insulin secretion in response to both glucose and IBMX.
No enhanced hormone output was observed in the radiation medium.

Conclusions:

Higher irradiation doses negatively impact in vitro insulin release from pancreatic islets.
These findings necessitate careful consideration of radiation doses for radioimmunosuppression in islet transplantation protocols.