The H-Y antigen and its functions: a review and a hypothesis

Having reviewed the status of H-Y as the sex-determining antigen concerned with the differentiation of the dominant gonad, we consider some of the problems deriving from the tests for this antigen, and from their application to the study of natural experiments. To reconcile the results of these studies with the alleged influence of H-Y on gonadal development, we propose and discuss a hypothesis on the genetic control of the synthesis of this antigen. This states that an autosomally-coded, positively cross-reacting precursor is rendered biologically active by a Y-chromosomal gene, and transformed (in a dose-dependent manner) into a biologically inactive, antigenically negative substance under the influence of an X-chromosomal gene.