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Related Experiment Videos

The relationship between function and DNA sequence in an intercistronic regulatory region in phage lambda.

M Rosenberg, D Court, H Shimatake

    Nature
    |March 30, 1978
    PubMed
    Summary
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    Bacteriophage lambda

    Area of Science:

    • Molecular biology
    • Genetics
    • Virology

    Background:

    • Bacteriophage lambda's lifecycle involves a critical decision between lytic and lysogenic growth.
    • Transcription termination plays a key role in regulating this decision.

    Purpose of the Study:

    • To investigate rho factor-mediated transcription termination at the bacteriophage lambda tr1 terminator.
    • To characterize mutations affecting termination and identify key features of the terminator site.
    • To define regulatory elements in the vicinity of the termination site.

    Main Methods:

    • Site-directed mutagenesis of the tr1 terminator region.
    • Analysis of transcription termination efficiency.
    • Identification and characterization of regulatory elements.

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    Main Results:

    • Mutations were identified that affect rho factor-mediated termination at the tr1 site.
    • Specific features of the tr1 terminator important for its function were defined.
    • Transcriptional and translational regulatory elements were identified near the terminator.

    Conclusions:

    • The tr1 terminator site and surrounding regulatory elements are crucial for bacteriophage lambda's growth pattern decision.
    • Interactions between these elements likely couple termination with the lytic-lysogenic switch.