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Consistent association between sigma elements and tRNA genes in yeast.

G M Brodeur, S B Sandmeyer, M V Olson

    Proceedings of the National Academy of Sciences of the United States of America
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Sigma elements are transposable genetic elements in yeast (Saccharomyces cerevisiae) that show a strong association with transfer RNA (tRNA) genes. This study confirms their widespread presence and close link to tRNA gene families.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Yeast Genomics

    Background:

    • Sigma elements are a recently identified family of transposable elements in yeast.
    • Previous studies noted sigma elements upstream of specific tRNA genes, but the full extent of this association was unknown.

    Purpose of the Study:

    • To globally characterize the sigma transposable element family in Saccharomyces cerevisiae.
    • To determine the prevalence and genomic distribution of sigma elements.
    • To investigate the relationship between sigma elements and other gene families, particularly tRNA genes.

    Main Methods:

    • Genomic analysis of a laboratory yeast strain.
    • Cloning and sequencing of 25 sigma element loci.
    • Bioinformatic analysis of sigma element distribution and association with genes.

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    Main Results:

    • An estimated 30 copies of sigma elements are present in the haploid yeast genome.
    • 25 sigma element loci were cloned and analyzed, revealing mostly individual elements at dispersed sites.
    • All 25 analyzed sigma elements were found to be closely associated with tRNA-encoding regions.

    Conclusions:

    • The sigma transposable element exhibits an absolute association with tRNA gene families in yeast.
    • This finding expands our understanding of transposable element-host gene interactions in Saccharomyces cerevisiae.