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Lymphocyte function in the critically ill surgical patient.

A J McIrvine, J A Mannick

The Surgical Clinics of North America

|April 1, 1983

Summary

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Immune responses are often impaired in critically ill surgical patients, with cellular immunity typically depressed. Further research is needed to understand the mechanisms behind these lymphocyte function abnormalities.

Area of Science:

Immunology
Surgical Critical Care

Background:

Lymphocyte function is frequently altered in patients experiencing critical illness after surgery.
While antibody production remains debated, cellular immune responses are consistently suppressed.

Purpose of the Study:

To investigate the alterations in lymphocyte function in critically ill surgical patients.
To explore the potential mechanisms behind suppressed cellular immunity and lymphocyte hyporesponsiveness.

Main Methods:

Analysis of lymphocyte function in critically ill surgical patients.
Assessment of lymphocyte response to mitogenic and antigenic stimulation.
Investigation of suppressive serum factors affecting lymphocyte activation.

Main Results:

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Critically ill surgical patients commonly exhibit impaired lymphocyte function.
Cellular immune responses are routinely depressed in this patient population.
Patients with major trauma or burns often display anergy, with poor lymphocyte stimulation and presence of suppressive serum factors.

Conclusions:

Major surgical trauma, accidents, or burns can lead to suppressed cellular immunity and anergy.
The precise mechanisms causing these lymphocyte abnormalities in critically ill surgical patients require further elucidation.