[Activity of various lysosomal hydrolases in peripheral blood granulocytes in patients with multiple sclerosis]

The activity of acid phosphatase, acid and neutral proteases in the serum, white blood cells and lysosomal granules and in the supernatant of the lysosomal fraction of peripheral blood granulocytes was determined in 33 patients with multiple sclerosis. The control group included 20 clinically unaffected subjects. A rise in the activity of neutral proteases in white blood cells was demonstrated at the time of multiple sclerosis exacerbations and a fall in the activity of these enzymes in lysosomal granules with its simultaneous rise in the supernatant of the lysosomal fraction of granulocytes was observed.