Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antitumor activity of platinum complexes.

J Drobník

    Cancer Chemotherapy and Pharmacology
    |January 1, 1983
    PubMed
    Summary

    Platinum complexes show antitumor activity through DNA interaction, but their exact mechanism is unclear due to ligand detachment and protein binding in the body. Understanding these platinum-based drugs is crucial for cancer research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stiff substrates inhibit collagen accumulation via integrin α2β1, FAK and Src kinases in human atrial fibroblast and myofibroblast cultures derived from patients with aortal stenosis.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2023
    Same author

    Exendin-4 differentially modulates essential functions of human dermal fibroblasts under normoglycemic and hyperglycemic conditions.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021
    Same author

    Disruption of histamine/H<sub>3</sub> receptor signal reduces collagen deposition in cultures scar myofibroblasts.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2019
    Same author

    The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2016
    Same author

    Hypoxia-related brain dysfunction in forensic medicine.

    Advances in experimental medicine and biology·2014
    Same author

    Melatonin-induced glycosaminoglycans augmentation in myocardium remote to infarction.

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2014

    Area of Science:

    • Medicinal Chemistry
    • Pharmacology
    • Molecular Biology

    Background:

    • Platinum complexes are vital in cancer chemotherapy.
    • The precise mechanisms of their antitumor activity require further elucidation.
    • Understanding drug fate in vivo is critical for efficacy.

    Purpose of the Study:

    • To review and discuss current concepts on the antitumor activity of platinum complexes.
    • To explore potential mechanisms of action, including DNA interaction and cellular responses.
    • To highlight challenges in assessing drug efficacy due to pharmacokinetic factors.

    Main Methods:

    • Review of contemporary scientific literature on platinum-based anticancer drugs.
    • Discussion of proposed mechanisms of action, including DNA damage and repair pathways.
    • Analysis of pharmacokinetic and pharmacodynamic considerations, including ligand behavior and metabolism.

    Main Results:

    • Platinum complexes induce SOS functions in bacteria, suggesting analogous mechanisms in animal cells.
    • Ligand detachment and protein binding significantly alter the administered compound's structure and concentration at the target site.
    • Drug reactivity and solubility influence platinum inactivation and excretion, complicating dose-response assessments.

    Conclusions:

    • The in vivo transformation of platinum complexes necessitates a deeper understanding of their pharmacokinetics.
    • Variability in drug fate impacts the quantity reaching target DNA, affecting therapeutic outcomes.
    • Further research into coordination anticancer drugs offers insights into cancer biology and potential reversal strategies.

    Related Experiment Videos