Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epithelial patchy necrosis in Crohn's disease.

R R Dourmashkin, H Davies, C Wells

    Human Pathology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Failure of the femoral stem: A case series of intra-prosthetic fractures and proposed classification system.

    Journal of orthopaedics·2026
    Same author

    Pain after lower limb amputation.

    BJA education·2026
    Same author

    Implementation considerations for integrated face and respiratory protection: a qualitative study.

    The Journal of hospital infection·2025
    Same author

    The risk of revision surgery after trainee-led primary total hip replacement.

    Annals of the Royal College of Surgeons of England·2024
    Same author

    Molecular signatures of cortical expansion in the human foetal brain.

    Nature communications·2024
    Same author

    Molecular signatures of cortical expansion in the human fetal brain.

    bioRxiv : the preprint server for biology·2024

    Crohn's disease shows patchy superficial epithelial damage without inflammation in rectal biopsies. This finding, observed via microscopy, was unique to Crohn's disease patients in a blind study.

    Area of Science:

    • Gastroenterology
    • Pathology
    • Cell Biology

    Background:

    • Crohn's disease is a chronic inflammatory bowel disease.
    • Intestinal epithelium damage is a hallmark of gastrointestinal disorders.
    • Microscopic examination is crucial for diagnosing intestinal diseases.

    Purpose of the Study:

    • To investigate the microscopic features of the intestinal epithelium in Crohn's disease.
    • To identify specific pathological findings in rectal biopsies from Crohn's disease patients.
    • To differentiate Crohn's disease from ulcerative colitis and normal controls using histological data.

    Main Methods:

    • Electron and light microscopy were used to examine intestinal epithelial tissues.
    • A blind study design was employed for rectal biopsy analysis.

    Related Experiment Videos

  • Biopsy specimens were collected from patients with Crohn's disease, ulcerative colitis, and healthy individuals.

    • Main Results:

    • Localized damage to the superficial intestinal epithelium was observed in Crohn's disease.
    • This epithelial damage occurred without signs of acute inflammation.
    • Patchy necrosis without acute inflammation was exclusively found in four out of seven Crohn's disease cases.

    Conclusions:

    • Microscopic analysis reveals distinct superficial epithelial damage in Crohn's disease.
    • The absence of acute inflammation alongside patchy necrosis is a key histological feature.
    • This finding aids in the differential diagnosis of inflammatory bowel diseases.