Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated plasma catecholamines in hypertensives with primary glomerular diseases.

M Ishii, T Ikeda, M Takagi

    Hypertension (Dallas, Tex. : 1979)
    |July 1, 1983
    PubMed
    Summary

    Hypertension in glomerulonephritis patients, even without severe kidney damage, is linked to higher norepinephrine, epinephrine, and aldosterone levels. Deteriorating renal function contributes to elevated blood pressure in these patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interleukin-2 receptor gamma-chain mutations in severe combined immunodeficiency with B-lymphocytes.

    European journal of pediatrics·1996
    Same author

    Standard RUS skeletal maturation of Tokyo children.

    Annals of human biology·1996
    Same author

    Acute megakaryo-monocytic leukemia with acute myelofibrosis.

    American journal of hematology·1996
    Same author

    MHC class II restriction for T cell proliferative response to mite antigen.

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·1996
    Same author

    [Successful UFT-E granule and 5-FUCDDP combination therapy for an unresectable advanced gastric cancer complicated with liver metastasis].

    Gan to kagaku ryoho. Cancer & chemotherapy·1996
    Same author

    [Continuous hepatic arterial infusion chemotherapy with low-dose CDDP plus 5-FU for liver metastases from colorectal carcinoma].

    Gan to kagaku ryoho. Cancer & chemotherapy·1996

    Area of Science:

    • Nephrology
    • Cardiovascular Medicine
    • Endocrinology

    Background:

    • Glomerulonephritis can lead to hypertension, even in early stages before significant azotemia.
    • The role of the sympathetic nervous system and renin-aldosterone system in this hypertension is not fully understood.

    Purpose of the Study:

    • To investigate plasma catecholamine levels, aldosterone, renin activity, and renal function in patients with glomerulonephritis.
    • To compare these parameters between normotensive and hypertensive patients with glomerulonephritis and healthy controls.

    Main Methods:

    • Measured plasma norepinephrine, epinephrine, aldosterone, and plasma renin activity in 36 patients and 20 controls.
    • Determined renal clearances of p-aminohippurate and creatinine.
    • Used high-pressure liquid chromatography for catecholamine measurement.

    Related Experiment Videos

    Main Results:

    • Hypertensive glomerulonephritis patients had significantly higher blood pressure, plasma norepinephrine, epinephrine, aldosterone, and plasma renin activity compared to normotensive patients and controls.
    • Renal clearances were significantly lower in hypertensive nephritic patients.
    • Blood pressure strongly correlated with plasma norepinephrine and moderately with other measured variables.

    Conclusions:

    • Deteriorating renal function is a key factor in hypertension development in non-azotemic glomerulonephritis patients.
    • Increased sympathetic nervous system and renin-aldosterone system activity contribute to elevated blood pressure in these patients.
    • Further research is needed to elucidate the mechanisms of catecholamine elevation.