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Related Experiment Videos

Relationship between plasma norepinephrine and sympathetic neural activity.

D S Goldstein, R McCarty, R J Polinsky

    Hypertension (Dallas, Tex. : 1979)
    |July 1, 1983
    PubMed
    Summary

    Plasma norepinephrine (NE) levels can accurately reflect sympathetic nervous system activity. This study presents a model showing venous plasma NE is a useful indicator of average sympathetic outflow, considering removal processes and regional blood flow.

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    Glucagon does not affect catecholamine release in primary cultures of bovine adrenal chromaffin cells.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2005

    Area of Science:

    • Physiology
    • Neuroscience
    • Pharmacology

    Background:

    • Circulating norepinephrine (NE) is a potential indicator of sympathetic nervous system (SNS) activity.
    • Valid reflection requires intensity-dependent changes and correlation with direct measures of sympathetic activity.

    Purpose of the Study:

    • To evaluate if peripheral plasma NE accurately reflects SNS activity.
    • To develop a model accounting for NE removal and regional contributions to plasma NE.

    Main Methods:

    • Reviewed published evidence on plasma NE and SNS activity.
    • Developed a model considering NE removal processes and arteriovenous NE differences across vascular beds.
    • Calculated contributions of specific vascular beds based on cardiac output distribution.

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    Main Results:

    • Published evidence supports peripheral plasma NE as a valid indicator of SNS activity.
    • The proposed model accounts for intervening processes between synapse and circulation.
    • Venous plasma NE generally provides a useful estimation of average sympathetic outflow.

    Conclusions:

    • Plasma norepinephrine is a valid surrogate for sympathetic nervous system activity.
    • A comprehensive model is presented to understand circulating NE dynamics.
    • Venous NE measurements offer a practical estimation of overall sympathetic tone.