Antilymphocyte autoantibody in lethal mouse malaria and its suppression by non-lethal malaria

Mice infected with lethal P. berghei or P. yoelii malaria develop anti-lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T-dependent and cytotoxic to a subpopulation of non-T lymphocytes at 37 degrees C in the presence of mouse or guinea-pig complement. Non-lethal P. yoelii and P. chabaudi do not induce these autoantibodies. X-irradiated P. berghei parasites induce autoantibodies in normal mice but not in mice infected with non-lethal P. yoelii suggesting an active suppressor mechanism in the non-lethal infection.