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[Lipids, lipoproteins, apoproteins and clinical arteriopathic manifestations]
Pathologie-Biologie
|April 1, 1983
Insights
This review covers historical data linking atherosclerosis complications to plasma lipids, lipoproteins, and apolipoproteins. It explores the clinical applications of this research.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Epidemiology
Context:
- Atherosclerosis is a major cause of cardiovascular disease.
- Understanding the relationship between lipids and atherosclerosis is crucial for prevention and treatment.
- Historical data provides a foundation for current research.
Purpose:
- To review the historical epidemiologic and pathophysiologic data supporting the link between atherosclerosis complications and various plasma lipid and lipoprotein components.
- To examine the evolution of understanding from plasma lipids to apolipoproteins in relation to atherosclerosis.
- To consider the clinical applications derived from these scientific findings.
Summary:
- The review traces the scientific understanding of atherosclerosis, starting from early observations on plasma lipids (cholesterol, triglycerides) and lipoproteins.
- It highlights the progression to more refined analyses, including lipoprotein lipids and the current focus on plasma apolipoproteins.
- The authors connect these pathophysiologic findings to their clinical implications in managing atherosclerosis.
Impact:
- Provides a comprehensive historical perspective on atherosclerosis research.
- Informs current clinical practice by contextualizing the role of lipids and lipoproteins.
- Supports the development of targeted therapies for cardiovascular disease prevention and management.
Abstract:
The authors present a historical review of the epidemiologic and pathophysiologic data which have supported the relations between the clinical complications of atherosclerosis on one hand, plasma lipids (cholesterol and triglycerides), lipoproteins (on electrophoretic basis), lipoproteins lipids (separated by ultracentrifugation or precipitation), and currently the plasma apolipoproteins on the other hand. The clinical applications of these data are considered.