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[Norbornane compounds in pharmaceutical research].

G Buchbauer, S Esterer, C Cermak

    Die Pharmazie
    |March 1, 1983
    PubMed
    Summary
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    Norbornanes and related bicyclo[2.2.1]heptanes are increasingly important in drug research. Their unique structure makes them valuable for medicinal applications and studying structure-activity relationships.

    Area of Science:

    • Medicinal Chemistry
    • Organic Chemistry

    Context:

    • Norbornanes and bicyclo[2.2.1]heptanes are bicyclic organic compounds.
    • Their unique structural features have garnered attention in pharmaceutical research.

    Purpose:

    • To review the literature on norbornanes and bicyclo[2.2.1]heptanes in drug research.
    • To highlight their medicinal applications and utility in structure-activity relationship (SAR) studies.

    Summary:

    • The review covers the period from 1967 to 1980, detailing the growing significance of these compounds.
    • Norbornanes are utilized as active pharmaceutical ingredients and as model systems for SAR investigations.
    • Their rigid, bicyclic carbon skeleton and fixed substituent positions facilitate detailed molecular analysis.

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    Impact:

    • Demonstrates the expanding role of specific molecular scaffolds in drug discovery.
    • Provides insights into the use of norbornanes for understanding drug-receptor interactions.
    • Establishes the value of these compounds beyond direct therapeutic use, as tools for chemical biology.