[Multicenter study on the litholytic effect of ursodeoxycholic acid. 30 cases]

Area of Science:

• Hepatology and Gastroenterology
• Pharmacology
• Biliary System Diseases

Background:

• Radiotransparent gallstones pose a clinical challenge.
• Non-invasive treatment options for gallstones are sought.
• Ursodeoxycholic acid is a potential litholytic agent.

Purpose of the Study:

• To evaluate the litholytic efficacy of ursodeoxycholic acid (Ursochol) in patients with radiotransparent gallstones.
• To assess the impact of ursodeoxycholic acid on gallstone-related symptoms.
• To determine the safety and tolerance of ursodeoxycholic acid treatment.

Main Methods:

• A cooperative clinical trial involving 42 patients with radiotransparent gallstones.
• Administration of ursodeoxycholic acid at a daily dose of 9 mg/kg.
• Follow-up for up to 1 year to assess gallstone dissolution and symptom changes.

Main Results:

• A litholytic effect was observed in 73% of 30 patients.
• Complete gallstone dissolution was achieved in 40% of cases.
• Significant reduction in dyspeptic symptoms and biliary colics (p < 0.001).

Conclusions:

• Ursodeoxycholic acid demonstrates significant litholytic efficacy for radiotransparent gallstones.
• The treatment effectively alleviates gallstone-related pain and discomfort.
• Ursodeoxycholic acid is well-tolerated, with no observed cases of diarrhea.