Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pseudohypoaldosteronism.

M Keszler, K N Sivasubramanian

    American Journal of Diseases of Children (1960)
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Pseudohypoaldosteronism can present very early in premature infants, causing severe hyponatremia and fluid loss. Kidney maturation plays a key role in resolving this condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    International survey on periextubation practices in extremely preterm infants.

    Archives of disease in childhood. Fetal and neonatal edition·2015
    Same author

    Developing a neonatal unit ventilation protocol for the preterm baby.

    Early human development·2012
    Same author

    State of the art in conventional mechanical ventilation.

    Journal of perinatology : official journal of the California Perinatal Association·2009
    Same author

    Evolution of tidal volume requirement during the first 3 weeks of life in infants <800 g ventilated with Volume Guarantee.

    Archives of disease in childhood. Fetal and neonatal edition·2008
    Same author

    High-frequency jet ventilation improves gas exchange in extremely immature infants with evolving chronic lung disease.

    American journal of perinatology·2006
    Same author

    Neonatal high-frequency ventilation. Past, present, and future.

    Clinics in perinatology·2001
    Same journal

    Nonsteroidal anti-inflammatory drugs and gastrointestinal injury in children.

    American journal of diseases of children (1960)·1993
    Same journal

    Picture of the month. Cutaneous leishmaniasis.

    American journal of diseases of children (1960)·1993
    Same journal

    Pathological case of the month. Wells' syndrome.

    American journal of diseases of children (1960)·1993
    Same journal

    Radiological case of the month. Proteus syndrome: benign angiolipomatous tumor with intraspinal extension.

    American journal of diseases of children (1960)·1993
    Same journal

    Applicability of the Greulich and Pyle skeletal age standards to black and white children of today.

    American journal of diseases of children (1960)·1993
    Same journal

    Maltreatment of children born to cocaine-dependent mothers.

    American journal of diseases of children (1960)·1993
    See all related articles

    Area of Science:

    • Neonatal Medicine
    • Pediatric Nephrology
    • Endocrinology

    Background:

    • Respiratory distress syndrome (RDS) is common in premature infants.
    • Pseudohypoaldosteronism (PHA) is a rare salt-wasting disorder typically diagnosed later in infancy.
    • Early diagnosis and management of neonatal electrolyte imbalances are critical.

    Observation:

    • A premature male infant (1,860g) at 32 weeks' gestation presented with severe hyponatremia, brisk diuresis, and rapid weight loss shortly after birth, despite aggressive fluid and sodium replacement.
    • Normal serum cortisol and low 17-OH progesterone levels were noted.
    • The infant did not respond to dexamethasone or desoxycorticosterone acetate treatment.

    Findings:

    • Elevated serum aldosterone levels and plasma renin activity confirmed the diagnosis of pseudohypoaldosteronism.

    Related Experiment Videos

  • Renal function studies were within the normal range for the infant's gestational age.
  • The condition's early and severe presentation was attributed to the immaturity of the proximal renal tubule at 32 weeks' gestation.

    • Implications:

    • This case highlights the possibility of very early pseudohypoaldosteronism presentation in extremely premature infants.
    • The findings underscore the critical role of renal tubule maturation in resolving PHA.
    • Understanding these early presentations is vital for timely diagnosis and intervention in neonatal intensive care units.