Recent developments in mass spectrometry for the analysis of complex mixtures
Annual Review of Pharmacology and Toxicology
|January 1, 1983
Summary
Advanced mass spectrometry techniques, including negative chemical ionization (NCI) and tandem mass spectrometry (MS/MS), offer powerful solutions for complex analytical challenges in environmental and food safety. These methods provide sensitive detection of harmful compounds, improving screening capabilities.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
- Environmental Science
Background:
- Complex analytical problems in food, drug, and environmental analysis require sophisticated tools.
- Traditional mass spectrometry faced limitations with polar or thermally labile compounds.
- Emerging mass spectrometry techniques address these challenges.
Purpose of the Study:
- To review recent advancements in mass spectrometry for analytical chemistry.
- To highlight the utility of negative chemical ionization and tandem mass spectrometry.
- To discuss new ionization techniques for challenging sample types.
Main Methods:
- Negative chemical ionization mass spectrometry (NCIMS) for trace analysis of oxidizing and alkylating agents.
- Tandem mass spectrometry (MS/MS) for rapid identification of specific organic compounds in mixtures.
- Development of novel ionization techniques like desorption chemical ionization, fast atom bombardment, secondary ionization, and 252Cf plasma desorption.
Main Results:
- NCIMS is a powerful screening tool for environmental samples, detecting carcinogens.
- MS/MS enables near-instantaneous isolation and identification of target compounds with minimal sample prep.
- New ionization methods overcome limitations of vaporizing and analyzing polar/labile compounds.
Conclusions:
- Negative chemical ionization mass spectrometry use is expected to grow due to its effectiveness in detecting environmental health hazards.
- Tandem mass spectrometry offers significant advantages for specific compound analysis, despite cost barriers.
- Continued research and development in ionization/desorption processes and instrumentation will make these advanced MS techniques more accessible.
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