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Published on: April 3, 2018

[Oncogene]

K Hagino-Yamagishi, K Toyoshima

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |July 1, 1983
    PubMed

    Insights

    Retroviruses can cause cancer by integrating viral oncogenes into host DNA. Researchers are now exploring links between these oncogenes, cellular oncogenes, and chromosomal changes in human cancers.

    Area of Science:

    • Oncology
    • Virology
    • Molecular Biology

    Context:

    • Retroviruses are known for their ability to induce neoplasms (tumors) in animals.
    • Viral oncogenes, responsible for cell transformation, are believed to arise from recombination between retroviruses and cellular oncogenes.
    • Recent studies have identified cellular oncogenes in human cancers using DNA transfection, with some showing homology to known viral oncogenes.

    Purpose:

    • To investigate the origin and role of viral and cellular oncogenes in carcinogenesis.
    • To explore the relationship between identified oncogenes and chromosomal translocations in cancer development.

    Summary:

    • This research focuses on retroviruses and their oncogenic potential, particularly the role of viral oncogenes derived from cellular DNA.
    • The study highlights the identification of cellular oncogenes in human cancers, some related to viral oncogenes.
    • Current research is examining the connection between these oncogenes and chromosomal translocations implicated in cancer.

    Impact:

    • Understanding the mechanisms of retroviral oncogenesis and the role of oncogenes in human cancers.
    • Potential for identifying new diagnostic markers or therapeutic targets for cancer based on oncogene and chromosomal aberration research.

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