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Related Concept Videos

Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

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Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
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'Vomiting center' reanalyzed: an electrical stimulation study.

A D Miller, V J Wilson

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    |June 27, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Brainstem electrical stimulation in cats only sometimes induced vomiting, with reproducible results rare. Effective sites were in the solitary tract and reticular formation, but a specific

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    Area of Science:

    • Neuroscience
    • Physiology

    Background:

    • The neural control of vomiting is complex.
    • Previous research suggests brainstem involvement in emesis.

    Purpose of the Study:

    • To investigate the localization of a potential 'vomiting center' in the brainstem through electrical stimulation.
    • To determine the reproducibility of stimulus-bound vomiting in decerebrate cats.

    Main Methods:

    • Electrical stimulation of the brainstem in 15 decerebrate cats.
    • Recording of stimulus-bound vomiting responses.
    • Identification of effective stimulation sites within the brainstem.

    Main Results:

    • Stimulus-bound vomiting was elicited in only 4 out of 15 cats.
    • Reproducible vomiting responses were observed in only one cat.
    • Effective stimulation sites were identified in the solitary tract and reticular formation.

    Conclusions:

    • A discrete and localized 'vomiting center' in the brainstem, stimulation of which reliably evokes vomiting, could not be identified.
    • The neural circuitry for vomiting may be more diffuse or complex than previously assumed.
    • Further research is needed to fully elucidate the brainstem's role in emesis.