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Related Experiment Videos

Lactic acidosis: current concepts.

R Park, A I Arieff

    Clinics in Endocrinology and Metabolism
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Lactic acidosis treatment is being re-examined. Alkali therapy may worsen the condition, while dichloroacetate shows promising results in early studies for managing lactate levels.

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    Area of Science:

    • Clinical Medicine
    • Biochemistry
    • Pathophysiology

    Background:

    • Lactic acidosis is a recognized clinical disorder.
    • Lactate disposal mechanisms are crucial in its pathogenesis.
    • Impaired liver function limits lactate clearance.

    Purpose of the Study:

    • To re-examine conventional lactic acidosis treatment.
    • To evaluate the efficacy of sodium bicarbonate and dichloroacetate.

    Main Methods:

    • Review of experimental studies on lactate disposal.
    • Analysis of the effects of alkali and dichloroacetate therapies.

    Main Results:

    • Alkali therapy may exacerbate lactic acidosis by impairing cardiovascular and hepatic functions.
  • Dichloroacetate therapy demonstrates significant benefits in experimental models.

    • Conclusions:

    • Conventional sodium bicarbonate treatment for lactic acidosis warrants re-evaluation.
    • Dichloroacetate presents a potentially effective alternative therapy for lactic acidosis.