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Timolol treatment after myocardial infarction in diabetic patients

T Gundersen, J Kjekshus

    Diabetes Care
    |May 1, 1983
    PubMed

    Insights

    Long-term timolol treatment significantly reduced mortality and reinfarction in diabetic patients post-myocardial infarction. Diabetic patients responded similarly to non-diabetic patients, though slight carbohydrate intolerance was noted.

    Area of Science:

    • Cardiology
    • Diabetology
    • Pharmacology

    Background:

    • Diabetic patients face increased risks following myocardial infarction.
    • Beta-blocker therapy is standard post-myocardial infarction, but data in diabetics is limited.

    Purpose of the Study:

    • To evaluate the efficacy of long-term timolol treatment in diabetic patients after myocardial infarction.
    • To compare outcomes between diabetic patients receiving timolol and placebo.

    Main Methods:

    • Retrospective analysis of 99 diabetic patients from the Norwegian timolol multicenter study.
    • Timolol dosage: 10 mg twice daily; follow-up: 12-33 months (mean 17 months).

    Main Results:

    • Timolol reduced overall mortality by 62.8% (P<0.05) and nonfatal reinfarction by 82.7% (P<0.05) compared to placebo.
    • Diabetic patients showed similar responses in side effects and withdrawals as non-diabetic patients.
    • A potential for slight carbohydrate intolerance with long-term timolol use was observed.

    Conclusions:

    • Long-term timolol treatment is associated with significant reductions in mortality and reinfarction in diabetic patients post-myocardial infarction.
    • Diabetic patients tolerated timolol similarly to non-diabetic patients.
    • Prospective studies are needed to confirm these findings and monitor for carbohydrate intolerance.

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