Cytogenetic evaluation of bone marrow cells from rats exposed to styrene vapor for one year

This report presents the cytogenetic findings in bone marrow cells of rats exposed to styrene vapor. Male and female Sprague-Dawley rats were exposed to 0,600 and 1000 ppm of styrene vapor by inhalation 6 hr per day, 5 days a week, for a period of one yr. Blind scoring of metaphase spreads prepared from bone marrow cells collected at the end of the last exposure revealed that neither the 600 ppm nor the 1000 ppm exposures to styrene vapor produced an incidence of chromosomal anomalies higher than those occurring spontaneously. It is interpreted that styrene is non-clastogenic within the present exposure regimen.