[In vitro activity of azthreonam on hospital Gram-negative bacilli. Results of a multicenter study]

This work reports a multicenter study of antibacterial activity of azthreonam, a new antibacterial agent of the monobactam group, on Gram negative rods. Enterobacteriaceae are very sensitive to azthreonam (modal MIC: 0,06 micrograms/ml); some strains have higher MIC greater than or equal to 8 micrograms/ml, particularly among Enterobacter, Serratia and Citrobacter. Azthreonam has a good activity on Pseudomonas aeruginosa: 90% of the strains are inhibited by 8 micrograms/ml or less. Acinetobacter are less sensitive with a modal MIC of 32 micrograms/ml. Haemophilus are inhibited by low concentrations, 0,06 to 0,12 micrograms/ml usually.