[Growth curves of Escherichia coli submitted to fosfomycin]

In the presence of glucose-6-phosphate, the growth curves of Escherichia coli submitted to several concentrations of fosfomycin show: a) a delay of growth of the bacteria at concentrations 16 to 32 times lower than the minimum inhibitory concentration, b) the presence of resistant bacteria in regrowing cultures under subinhibitory concentrations.