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[Diffusion of fosfomycin into bone tissue in man].
Pathologie-Biologie
|June 1, 1983
Summary
Fosfomycin (FOM) effectively penetrates bone tissue, reaching significant concentrations in both spongious and cortical bone after intravenous administration. Bone antibiotic levels correlate with serum concentrations, indicating FOM
Area of Science:
- Pharmacokinetics
- Bone Biology
- Infectious Diseases
Context:
- Assessing antibiotic penetration into bone is crucial for treating osteomyelitis.
- Fosfomycin is a broad-spectrum antibiotic with potential utility in bone infections.
- Total hip replacement surgeries provide an opportunity to study drug distribution in bone tissue.
Purpose:
- To quantify fosfomycin concentrations in human serum, spongious bone, and cortical bone.
- To determine the relationship between serum and bone concentrations of fosfomycin.
- To evaluate the efficacy of intravenous fosfomycin for achieving therapeutic levels in bone.
Summary:
- This study measured fosfomycin levels in serum and bone samples from 20 patients receiving 4g IV infusion.
- Peak concentrations were observed 1 hour post-infusion, with significant levels detected in both serum and bone.
- Bone fosfomycin concentrations decreased over 3 hours, mirroring serum level decline, with a consistent tissue/serum ratio of approximately 15%.
Impact:
- Provides essential pharmacokinetic data for fosfomycin in bone tissue.
- Informs clinical decisions regarding the use of fosfomycin for bone infections.
- Highlights the importance of considering drug distribution in bone when selecting antibiotic therapy.