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Related Experiment Videos

Acute vascular rejection treated by plasma exchange.

W Fassbinder, W Ernst, H J Stutte

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1983
    PubMed
    Summary

    Plasma filtration effectively reverses acute vascular rejection in kidney transplant patients. This treatment improves renal function and long-term graft survival, offering a safe and simple therapeutic option.

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    Humanized mice in infectious diseases.

    Comparative immunology, microbiology and infectious diseases·2016

    Area of Science:

    • Nephrology
    • Immunology
    • Transplantation

    Background:

    • Acute vascular rejection (AVR) is a significant complication following kidney transplantation.
    • Steroid-resistant AVR poses a challenge in managing graft survival.

    Purpose of the Study:

    • To evaluate the efficacy and safety of plasma filtration (PF) in treating steroid-resistant acute vascular rejection (AVR).

    Main Methods:

    • Treatment involved six sessions of plasma filtration, replacing 5L of plasma with Albumin-Ringer-lactate.
    • Intravenous immunoglobulin (20g) was administered after each PF session.
    • The study included 14 patients experiencing 19 episodes of AVR since 1980.

    Main Results:

    • All patients showed improved renal function post-treatment.

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  • One graft was lost to chronic rejection; the remaining grafts were functioning at 6 and 12 months post-treatment.
  • No signs of rejection were observed in the functioning grafts at follow-up.

    • Conclusions:

    • Plasma filtration combined with immunoglobulin repletion is a safe and effective method for reversing acute vascular rejection.
    • This therapeutic approach demonstrates promising long-term graft survival rates.