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Related Experiment Videos

Iohexol for excretory urography: a comparative study.

A C Winfield, R J Dray, F K Kirchner

    AJR. American Journal of Roentgenology
    |September 1, 1983
    PubMed
    Summary
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    Iohexol, a new nonionic contrast agent, showed fewer side effects and better imaging quality than the ionic agent Renografin 60 in excretory urography. This study highlights Iohexol

    Area of Science:

    • Radiology
    • Medical Imaging
    • Pharmacology

    Background:

    • Ionic contrast agents like Renografin 60 have been widely used for excretory urography.
    • Nonionic contrast agents offer potential advantages in terms of patient tolerance and image quality.

    Purpose of the Study:

    • To compare the safety and efficacy of a new iodinated nonionic contrast agent, Iohexol, with an established ionic contrast agent, Renografin 60.
    • To evaluate the incidence of adverse events and the quality of excretory urograms.

    Main Methods:

    • A double-blind study involving 55 patients with normal renal function.
    • Patients received either Iohexol or Renografin 60 for excretory urography.
    • Adverse side effects and the quality of the resultant urograms were assessed.

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    Main Results:

    • No major adverse reactions were reported for either contrast agent.
    • Minor side effects occurred more than twice as frequently with Renografin 60 compared to Iohexol.
    • Excellent visualization of the collecting system was achieved in 44% of patients receiving Iohexol, versus 17% with Renografin 60.

    Conclusions:

    • Iohexol is a safe and effective nonionic contrast agent for excretory urography.
    • Iohexol demonstrates a superior side effect profile and improved image quality compared to Renografin 60.
    • The findings support the use of Iohexol for enhanced diagnostic accuracy in urography.