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Related Experiment Videos

[Multiple plasma exchanges in patients with advanced malignant disease].

I Urushizaki, K Ishitani

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |February 1, 1983
    PubMed
    Summary

    Multiple plasma exchange (PE) may enhance cancer immunotherapy by removing immunosuppressive factors. This study found PE improved immune responses and reduced serum inhibition in cancer patients, suggesting a role in treatment.

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    Area of Science:

    • Immunology
    • Oncology
    • Therapeutic Apheresis

    Background:

    • Cancer patients often exhibit immunosuppressive factors in their plasma.
    • Plasma exchange (PE) is an empirical approach to remove these factors.

    Purpose of the Study:

    • To evaluate the effects of multiple plasma exchanges on immune parameters in cancer patients.
    • To determine if PE can reduce immunosuppression and enhance immune responses.

    Main Methods:

    • 32 patients with advanced malignant disease underwent multiple plasma exchanges.
    • Up to 4000 ml of plasma was replaced per exchange.
    • Serum proteins, skin reactivity, and lymphocyte responses were monitored before and after PE.

    Main Results:

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    • A transient change in serum proteins was observed, with values returning to baseline.
    • Skin reactions to antigens were enhanced post-PE.
    • Lymphocyte blastogenic response to mitogen showed a slight increase.
    • PE significantly reduced the inhibitory effect of patient sera on normal lymphocyte reactivity.

    Conclusions:

    • Multiple plasma exchanges can reduce immunosuppression in cancer patients.
    • PE may enhance immune responses, suggesting a potential role in cancer immunotherapy.