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[Neuron-specific enolase as a new tumor marker].
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1983
Summary
Neuron-specific enolase (NSE) is a useful tumor marker for various cancers, particularly for monitoring disease extent. NSE production in lung adenocarcinomas and other tumors suggests shared neuroendocrine features.
Area of Science:
- Biochemistry
- Oncology
- Neuroscience
Context:
- Enolase is a glycolytic enzyme with alpha, beta, and gamma subunits.
- Neuron-specific enolase (NSE) comprises alpha gamma and gamma gamma isozymes.
- NSE is found in neuroendocrine cells and neuroendocrine tumors.
Purpose:
- To evaluate neuron-specific enolase (NSE) as a tumor marker in various cancers.
- To assess the clinical utility of serum NSE for monitoring disease extent.
- To investigate the neuroendocrine properties of different cancer types.
Summary:
- Neuron-specific enolase (NSE), a brain and neuroendocrine cell marker, was evaluated as a tumor marker.
- Serum NSE proved clinically useful, especially for monitoring disease extent in cancers like small cell lung carcinoma.
- NSE production was also observed in adenocarcinoma of the colon/lung and esophageal cancers, suggesting shared neuroendocrine features.
Impact:
- NSE is a valuable tumor marker for clinical medicine and basic research.
- Findings challenge the notion of a distinct origin for small cell lung carcinoma.
- The study highlights NSE's role in understanding neuroendocrine tumor biology.