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Murine lymphocyte cell surface proteolytic activity is strain related
Biochemical and Biophysical Research Communications
|July 29, 1983
Summary
Genetic differences in mice impact lymphoid cell surface proteolytic activity, a measure of immune response. A/J mice show higher activity than C57 Br/cdj mice, suggesting a link between proteolysis and immune responsiveness.
Area of Science:
- Immunology
- Genetics
- Biochemistry
Background:
- A/J and C57 Br/cdj mice possess H-2 haplotypes linked to high immune responses.
- A/J mice generally exhibit superior antibody production compared to C57 Br/cdj mice against specific antigens.
Purpose of the Study:
- To investigate if lymphoid cell surface proteolytic activity is genetically controlled.
- To determine the relationship between mouse strain, proteolytic activity, and immune responsiveness.
Main Methods:
- Utilized A/J and C57 Br/cdj mice as model systems.
- Assessed and compared lymphoid cell surface proteolytic activity between the two mouse strains.
Main Results:
- Lymphoid cell surface proteolytic activity demonstrated strain-specific differences.
- A/J lymphocytes exhibited significantly higher proteolysis rates than C57 Br/cdj lymphocytes.
Conclusions:
- Lymphoid cell surface proteolytic activity is genetically influenced and strain-related.
- A correlation is suggested between higher lymphoid cell surface caseinolytic activity and enhanced immune responsiveness.