Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of the Ca antigen.

M E Bramwell, V P Bhavanandan, G Wiseman

    British Journal of Cancer
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A phase 1 trial of <sup>90</sup>Y-Zevalin radioimmunotherapy with autologous stem cell transplant for multiple myeloma.

    Bone marrow transplantation·2017
    Same author

    Letter: switches of 5-aminosalicylates in ulcerative colitis, risk of relapse and ascertainment bias--authors' reply.

    Alimentary pharmacology & therapeutics·2014
    Same author

    Commentary: 5-ASA switches in IBD, adherence and flares--authors' reply.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Maintaining stable symptom control in inflammatory bowel disease: a retrospective analysis of adherence, medication switches and the risk of relapse.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Virolysis of feline calicivirus and human GII.4 norovirus following chlorine exposure under standardized light soil disinfection conditions.

    Journal of food protection·2011
    Same author

    The contribution of transfusion to HCV infection in England.

    Epidemiology and infection·2003
    Same journal

    Functional and omics-based rationale for the induction of BRCAness by androgen receptor pathway inhibitors to sensitize prostate cancer to PARP inhibition, regardless of HRR status.

    British journal of cancer·2026
    Same journal

    Oligometastatic neuroendocrine tumors: characteristics and prognosis.

    British journal of cancer·2026
    Same journal

    The concept of functional cure in advanced/metastatic melanoma treated with combined nivolumab and ipilimumab or nivolumab alone.

    British journal of cancer·2026
    Same journal

    Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.

    British journal of cancer·2026
    Same journal

    Altretamine induces ferroptosis in small cell lung cancer by promoting epigenetic silencing and lysosomal degradation of GPX4.

    British journal of cancer·2026
    Same journal

    Revisiting retinoic acid in AML therapy: mechanisms of action and rational combination strategies.

    British journal of cancer·2026
    See all related articles

    The Ca antigen, a mucin-type glycoprotein found in tumors, may protect cells from acidic environments. Its presence reflects tumor metabolic conditions, aiding in cancer research.

    Area of Science:

    • Biochemistry
    • Oncology
    • Cell Biology

    Background:

    • The Ca antigen is a mucin-type glycoprotein detected in various human malignant tumors using the Cal antibody.
    • It is characterized by a high proportion of glycine, serine, and glutamic acid in its polypeptide structure.
    • The carbohydrate moiety exhibits a simple structure, primarily composed of neutral trisaccharides and disaccharides.

    Purpose of the Study:

    • To investigate the structure and function of the Ca antigen.
    • To explore the relationship between Ca antigen synthesis and tumor metabolic conditions.
    • To determine the potential role of the Ca antigen in protecting tumor cells.

    Main Methods:

    • Detection of the Ca antigen using the Cal antibody in malignant human tumors.

    Related Experiment Videos

  • Analysis of the carbohydrate and polypeptide composition of the glycoprotein.
  • In vitro studies on Ca antigen synthesis in malignant cell lines, including induction by lactate.
  • Evaluation of the protective function of the Ca antigen against extracellular hydrogen ion concentrations.

    • Main Results:

    • The Ca antigen is a mucin-type glycoprotein with O-glycosidically linked carbohydrates.
    • Its carbohydrate structure is relatively simple, with a general formula (NeuNac)n → [Gal → GalNac]α→, where n = 0, 1, or 2.
    • Constitutive in vitro production of the antigen was observed in many malignant cell lines.
    • Lactate was found to induce Ca antigen synthesis in at least one examined cell line.
    • Evidence suggests the glycoprotein shields cells from non-physiological hydrogen ion concentrations.

    Conclusions:

    • The Ca antigen's structure and simple carbohydrate composition are elucidated.
    • Its constitutive production and inducibility by lactate in malignant cells are demonstrated.
    • The primary function of the Ca antigen is proposed to be cellular protection against acidic environments.
    • The presence of Ca antigen in tumors may indicate specific metabolic conditions characteristic of malignancy.