Note on the stability of mefloquine hydrochloride in aqueous solution

Using Desjardins' technique for the testing of antimalarials against Plasmodium falciparum in vitro, a 4-year-old solution of mefloquine in water (10(-3) mol/litre) was compared with a freshly prepared solution.The results showed that the two solutions had almost identical activity. There was no evidence for any instability of mefloquine in aqueous solution.