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Related Experiment Videos

Amiodarone: a unique antiarrhythmic agent.

G E Sloskey

    Clinical Pharmacy
    |July 1, 1983
    PubMed
    Summary

    Amiodarone is an effective antiarrhythmic drug for serious arrhythmias, but its use is limited by significant side effects. Further clinical data are needed to establish its full therapeutic role.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Amiodarone is an investigational antiarrhythmic agent.
    • It is a benzofuran derivative containing iodine, acting as a noncompetitive alpha- and beta-adrenergic antagonist.
    • It functions as a Type III antiarrhythmic, prolonging action potentials in atrial and ventricular tissues.

    Purpose of the Study:

    • To review the chemistry, pharmacology, pharmacokinetics, clinical use, efficacy, adverse effects, and dosage of amiodarone.
    • To assess its potential in treating various arrhythmias.

    Main Methods:

    • Review of existing literature on amiodarone.
    • Analysis of its pharmacological properties, absorption, distribution, metabolism, and elimination.
    • Evaluation of clinical trial data regarding its efficacy and safety profile.

    Main Results:

    • Amiodarone is variably absorbed orally, with a wide distribution and long terminal half-life (14-58 days).
    • It shows efficacy in supraventricular tachycardias (especially Wolff-Parkinson-White syndrome), atrial fibrillation/flutter, and ventricular arrhythmias.
    • Numerous serious side effects affecting cardiovascular, pulmonary, neurologic, hepatic, ocular, thyroid, and skin systems are reported.

    Conclusions:

    • Amiodarone is an effective agent for serious arrhythmias refractory to other treatments.
    • Its use is constrained by a significant and potentially severe side effect profile.
    • Restricted use is recommended until more comprehensive clinical data become available.

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