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Platelet estimation in whole blood.

Dilworth, O H Gyde, A J Ince

    Physics in Medicine and Biology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a particle size analysis method for estimating platelet counts in whole blood. The technique shows high correlation with traditional methods and potential for automated, semiquantitative screening.

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    Area of Science:

    • Hematology
    • Biomedical Engineering
    • Analytical Chemistry

    Background:

    • Accurate platelet counts are crucial for diagnosing and monitoring various medical conditions.
    • Traditional platelet counting methods can be time-consuming and require specialized equipment.
    • There is a need for efficient and potentially automated screening methods for platelet estimation.

    Purpose of the Study:

    • To describe a novel particle size analysis technique for estimating platelet counts in whole blood.
    • To evaluate the accuracy and reliability of this new method compared to established techniques.
    • To explore the potential for automation and application as a semiquantitative screening tool.

    Main Methods:

    • Utilized particle size analysis with a variable size threshold and baseline for platelet detection.

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  • Employed specially designed electronics to count particles within defined size ranges.
  • Divided the size distribution into four windows and performed three integrations for calculation.
  • Correlated results with the sedimentation method.

    • Main Results:

    • Achieved a high correlation coefficient of 0.93 when compared to the sedimentation method.
    • In a trial with 132 samples, only six false negative results were observed.
    • False negatives were predominantly at the lower and upper ends of the normal platelet count range.

    Conclusions:

    • Particle size analysis offers a promising approach for estimating platelet counts in whole blood.
    • The method's simplicity suggests potential for automation as a semiquantitative screening tool.
    • This technique demonstrates good accuracy and reliability, with minimal false negatives in initial trials.