[Changes in insulin secretion shortly after injury of the ventromedial hypothalamus]

In 8 series of the experiments on 95 rats changes in the immunoreactive insulin (IRI) and blood sugar content, as well as of the indices of insulin deposition in pancreatic islands, were studied 5 hours after the injure to the hypothalamic ventromedial nuclei (HVMN) and subsequent two-hour feeding of the animals. It was found that the blood sugar- and IRI levels are significantly lowered in rats 5 hours after HVMN affection, caused by vigorous emotional and motor excitation. The 2-hour feeding of the animals 5 hours after HVMN disturbance led to an increase in the glycemia and insulinemia (almost 5 times) levels.